As May draws to a close, strikeout prop betting in Major League Baseball is heating up, and the May 29 slate features some of the most exciting pitchers ready to dominate hitters. MacKenzie Gore MLB strikeout prop bet holds considerable appeal as the left-hander looks to exploit a swing-heavy Mariners lineup with his exceptional ability to rack up strikeouts.
This slate also showcases pitchers like Cristopher Sanchez, Jose Berrios, and several promising arms primed to deliver strong strikeout performances. Whether you are an experienced bettor or simply enjoying the action, today’s matchups offer compelling opportunities to back punch-out totals.
Top Pitchers with Strikeout Potential for Tonight’s MLB Games
Jose Berrios will take the mound against the Oakland Athletics carrying 56 strikeouts across 64 innings this season, maintaining a respectable 7.9 strikeouts per nine innings rate. Although his 4.22 ERA and 1.36 WHIP suggest some inconsistencies, Berrios’ sharp breaking pitches and well-commanded fastball make him a strong candidate to exceed the 5.5 strikeout line. The Athletics’ lineup has struggled against right-handers, ranking among the highest in strikeouts, which benefits Berrios in his chances to pile up Ks.
Ryan Gusto, a rookie right-hander, has shown genuine strikeout ability early in 2025, tallying 38 strikeouts over 35.1 innings with an impressive 9.7 K/9 rate. Though he carries a 4.58 ERA and 1.53 WHIP, reflecting some volatility, Gusto’s combination of mid-90s fastball velocity and sharp secondary pitches matches well against Tampa Bay’s habit of striking out against righties. If Gusto can improve his walk rate, which currently stands at 4.1 BB/9, he has solid value hitting over 4.5 strikeouts in this matchup.
MacKenzie Gore’s Dominance Against the Mariners’ Vulnerable Lineup
MacKenzie Gore has quietly established himself as one of MLB’s premier strikeout pitchers this season, amassing an astounding 93 strikeouts over 62.1 innings, translating to a dominant 13.4 K/9. His 3.47 ERA and 1.25 WHIP indicate some base runners, but the relentless swing-and-miss quality of his pitching remains undeniable. Gore enters tonight’s game facing a Mariners team that is particularly prone to strikeouts, especially against left-handed pitchers who throw with velocity and sharp breaking pitches.
If Gore can locate his pitches effectively and rely on his devastating wipeout offerings early in the game, he could very well notch another double-digit strikeout performance, continuing the trend he’s shown recently by clearing the 7.5 strikeout line in three of his last four starts.
Cristopher Sanchez Builds Momentum With High Strikeout Rate
Cristopher Sanchez has quietly become one of the more exciting pitchers in 2025, accumulating 65 strikeouts over 54 innings and maintaining a solid 3.17 ERA. His fastball-changeup combination has confounded hitters, forcing them to chase pitches outside the strike zone. Facing the Atlanta Braves, a team with plenty of power hitters but susceptible to strikeouts, Sanchez has demonstrated his ability to clear his strikeout targets consistently, surpassing the 5.5 Ks mark in four of his last five starts.
With an effective 10.8 strikeouts per nine innings pace and a reputation for missing bats in crucial moments, Sanchez stands out as one of the safer strikeout props to consider on this slate.
Jacob Lopez Emerges as a Sleeper Strikeout Option
Jacob Lopez may not yet be widely known, but his strikeout numbers have caught attention through limited innings pitched. In just 14 innings, Lopez has fanned 17 batters, equating to a sharp 10.9 K/9 rate, despite some control issues highlighted by his 5.1 walks per nine innings. The southpaw’s mix of velocity and movement has enabled him to slice through opposing lineups, and he has cleared the 3.5 strikeouts threshold in each of his last three outings.
Tonight, Lopez faces a Toronto Blue Jays lineup that has experienced streaky offensive performances. Offering a strong combination of strikeout upside and favorable odds, Lopez represents a high-reward pick for bettors willing to take a calculated risk on the mound.
The Value and Impact of Strong Strikeout Performances Tonight
Overall, the May 29 MLB slate offers a well-balanced selection of pitchers with strikeout upside and enticing matchups. MacKenzie Gore’s relentless ability to accumulate strikeouts makes him a standout figure for strikeout prop bets, especially against a Mariners team struggling against left-handed power pitching. Likewise, the contributions from Sanchez, Berrios, Gusto, and Lopez provide multiple angles of attack for bettors, from safe picks to high-upside candidates.
As these arms take the mound tonight, bettors will look to capitalize on favorable matchups and rising strikeout projections, underscoring the growing popularity and strategic importance of MLB strikeout prop betting.