The Kansas City Chiefs continue a remarkable stretch as one of the NFL’s most successful teams since 2016, securing nine consecutive AFC West division titles, five AFC Championships in six years, and three Super Bowl victories. Led by quarterback Patrick Mahomes and tight end Travis Kelce, along with head coach Andy Reid, the franchise is a dominant force in the league. Although the Chiefs fell to the Philadelphia Eagles 40-22 in last year’s Super Bowl, they remain positioned among the leading contenders for Super Bowl 60 in 2026. With Missouri’s new sports betting legalization set for late 2025, excitement is growing around how these developments will affect local betting on Kansas City’s quest for a fourth title in seven years.
While betting on the Chiefs to win Super Bowl 60 at +850 odds is a popular choice, there are more ambitious 2025 NFL betting options worth noting. One such wager is Kansas City scoring at least one rushing touchdown in every regular-season game, currently offering +2000 odds, presenting a rare and lucrative betting opportunity.
Expert Insights Highlight Bold Futures Bets on Chiefs’ Success
SportsLine handicapper Jimmie Kaylor has analyzed NFL futures betting trends and identified five notable bets for the Chiefs that stand out for the 2025 season. From player achievements to team performance in critical games, these predictions reveal high-stakes angles for bettors interested in exploring beyond the obvious Super Bowl wager. New bettors can also leverage promotional offers on top betting platforms to maximize their potential returns.
Chiefs’ Streak Will Pause at AFC Championship, According to Predictions
Kaylor expects Kansas City to continue its dominance by winning its 10th straight division crown and securing a favorable seed in the AFC playoffs. However, he anticipates that the Baltimore Ravens will ultimately defeat the Chiefs and represent the AFC in Super Bowl 60. This wager, priced at +550 on BetMGM, challenges the notion that Kansas City will reach the championship game once again, suggesting a tough road ahead.
George Karlaftis Poised to Break Sack Record in 2025
After proving his value over three seasons, the Chiefs made a substantial financial investment in defensive end George Karlaftis during the offseason. The former Purdue standout, a first-round pick in the 2022 NFL Draft, has accumulated 24.5 career sacks and is projected to surpass 10 sacks in the 2025 regular season for the second time in his career. DraftKings currently lists this prop bet at +160, reflecting confidence in Karlaftis’ continued growth as a premier pass rusher.
Mahomes Expected to Throw Passing Touchdowns in Every Game
Patrick Mahomes is widely regarded as one of the greatest quarterbacks of his generation, and achieving a passing touchdown in all 17 regular-season games is within his range. While the Chiefs managed this feat in 14 games during 2024, with Mahomes starting 16 of those, this consistent achievement remains uncommon in today’s NFL. Motivated by last season’s Super Bowl loss, Mahomes is expected to push harder in 2025. At +700 odds, this betting option offers significant potential value for fans anticipating a historic season.
Travis Kelce’s Enduring Threat as Top Red Zone Target
Despite signs that his career is winding down, Travis Kelce remains a formidable matchup challenge and a key red zone asset for the Chiefs. Alongside a talented wide receiver group that helps stretch opposing defenses, Kelce is expected to continue his high level of production. FanDuel currently prices the bet on Kelce recording 10 or more touchdown receptions at +600. This underscores that, even as he nears retirement, Kelce can still impact the Chiefs’ passing game significantly.
Mahomes Sets Sights on Surpassing 4,500 Passing Yards
Having started as the Chiefs’ primary quarterback for seven years, Patrick Mahomes has achieved at least 4,500 regular-season passing yards in four seasons. Bolstered by a strong mix of pass catchers, Mahomes is projected to deliver another MVP-worthy effort in 2025. DraftKings offers +300 odds on this outcome, highlighting the belief that Mahomes will continue to dominate through the air and elevate Kansas City’s offensive attack.
What Betting Fans Should Watch as the 2025 NFL Season Unfolds
As the Chiefs prepare for a challenging 2025 campaign, fans and bettors alike are closely watching player performance and team dynamics that could shape betting markets and outcomes. The combination of Mahomes’ skill, Kelce’s reliability, and emerging defensive talents like Karlaftis is expected to create numerous exciting wagers. The expansion of sports betting in Missouri adds a new dimension, potentially increasing engagement and betting interest for Chiefs’ games.
For football enthusiasts seeking additional insights, the SportsLine Projection Model offers constantly updated fantasy football projections, highlighting sleepers, breakout candidates, and busts. This data-driven tool outperformed human experts in 2024 and continues to provide valuable guidance for strategic betting decisions.
“I fully expect the Chiefs to win their 10th consecutive division title and end up with one of the top seeds in the AFC playoff bracket. But as I’ve said this offseason, the Baltimore Ravens are the team I believe will be representing the AFC in Super Bowl 60.”
—Jimmie Kaylor, SportsLine Expert Handicapper
“With Patrick Mahomes in the mix, this seems like a no-brainer. However, this is actually a rare accomplishment in today’s NFL.”
—Jimmie Kaylor, SportsLine Expert Handicapper
“There is no denying the end is near for Kelce as a NFL player. Nonetheless, the future Hall of Famer remains a matchup problem for opposing defenses, and is a force in the red zone.”
—Jimmie Kaylor, SportsLine Expert Handicapper