One of the most appealing betting strategies in Major League Baseball is focusing on player prop bets, as these allow bettors to avoid the unpredictability of bullpens and fluctuating team performances throughout the long 162-game season. The Bo Bichette home run prop stands out as an enticing option, offering potential for big rewards on Wednesday’s slate of games.
At SI Betting, daily insights into favored home run prop bets highlight some of the most promising players to help fans engage with the action and possibly enjoy significant payouts. By analyzing pitching matchups and how players have fared against specific starters, bettors can identify favorable opportunities.
Top Home Run Prop Bets to Consider for Wednesday’s MLB Games
DraftKings Sportsbook provides the following odds for key home run contributors on August 6:
- Bo Bichette to Hit a Home Run (+320)
- Ketel Marte to Hit a Home Run (+285)
- Bobby Witt Jr. to Hit a Home Run (+330)
- Wilmer Flores to Hit a Home Run (+600)
Bo Bichette’s Favorable Conditions at Coors Field
Toronto Blue Jays shortstop Bo Bichette has posted an impressive 2025 campaign, batting .300 with 15 home runs entering Wednesday’s series finale versus the Colorado Rockies. The game takes place at Coors Field, famed for its hitter-friendly environment, which offers an advantage in power hitting.
Facing Bichette will be Colorado’s left-handed pitcher Kyle Freeland, who has struggled this season, relinquishing 15 home runs in 20 appearances. Notably, Freeland has surrendered six home runs over his last three starts and carries a 5.26 ERA in 2025, setting the stage for Toronto’s offense to capitalize.
Bichette’s recent performance has been exceptional; he is hitting .404 over the past 28 days and .444 over the last six games with two homers in that span. His success against left-handed pitching this season is highlighted by an .856 OPS and five of his 15 home runs coming off southpaw pitchers despite limited chances. These factors combine to position Bichette as a strong candidate to hit a home run in this matchup.
Ketel Marte’s Power Against a New Opponent
Arizona Diamondbacks’ Ketel Marte remains a premier hitter amid roster changes following the trade deadline. The switch hitter boasts a .287 average with 21 home runs this year and is set to face San Diego Padres’ new pitcher Nestor Cortes, who recently returned from the 60-day injured list after being traded from the Milwaukee Brewers.
Cortes has allowed five homers in only two appearances this season, raising doubts about his ability to contain Arizona’s potent lineup, which ranks among the top 10 offensively in <a href="https://www.buzzineintl.com/category/baseball/mlb/”>MLB. Marte himself has a history against Cortes, recording a 1-for-3 performance with a double and five home runs across 109 at-bats versus left-handed pitchers this year, making him a solid option for a home run bet.
Bobby Witt Jr. Versus Boston’s Newest Arm Dustin May
Kansas City Royals’ star Bobby Witt Jr. will take on the Boston Red Sox, who will debut trade deadline acquisition Dustin May in their rotation. May, acquired from the Los Angeles Dodgers, carries a 4.85 ERA and has given up 16 home runs in 19 appearances this season.
Historically, May has faced Witt three times, allowing one hit—a home run. Witt has shown consistent power in 2025, launching 16 home runs exclusively against right-handed pitching. Recently, he has maintained a strong .925 OPS over 11 games, adding two home runs. These statistics suggest Witt offers a compelling home run prop pick in this contest.
The Long-Shot Bet: Wilmer Flores
Wilmer Flores of the San Francisco Giants is a riskier option due to a hamstring injury putting his participation in Wednesday’s game in doubt. However, if Flores takes the field, he faces Pittsburgh Pirates’ starter Andrew Heaney, who has struggled significantly, allowing 21 home runs in 22 appearances this season.
Flores is a formidable opponent for Heaney, batting .438 with a 1.221 OPS in 16 career at-bats against him, including a home run and two doubles. Flores also performs well against left-handed pitchers overall, with a .267 batting average and a .789 OPS. Given his track record and the generous +600 odds, Flores represents an attractive long shot if active.
Implications for Bettors and What to Watch Next
With these prop bets, especially the Bo Bichette home run prop at +320, bettors have the chance to benefit from strategic player matchups that exploit pitcher vulnerabilities and ballpark factors. The matchups for Witt Jr. and Marte also suggest potential for rewarding outcomes based on their hitting trends and opposing pitchers’ recent struggles.
As odds fluctuate throughout the day, monitoring lineups and injury reports, particularly for players like Flores, will be crucial for bettors aiming to maximize their return. These prop bets provide a focused way to engage with MLB action, sidestepping some of the unpredictability inherent in full-game outcomes.
Ultimately, these selections combine current player form, historical data, and advantageous matchups, which may offer bettors appealing opportunities on Wednesday’s MLB schedule.