
On Friday night, the National League West contenders will meet as the Los Angeles Dodgers host the San Diego Padres at 10:10 p.m. ET. San Diego holds a slim one-game advantage after an impressive run, and Manny Machado, the Padres’ standout third baseman, has been delivering consistent hits lately. With 20 home runs so far and a strong track record against Dodgers pitcher Clayton Kershaw, Manny Machado <a href="https://www.buzzineintl.com/category/baseball/mlb/”>MLB home run picks are drawing significant attention for bettors.
MLB’s Leading Home Run Contenders for August 15
The Padres’ recent success is largely fueled by Machado, who has hit safely in 17 of his last 20 games. This performance, combined with his notable edge over Kershaw—boasting four home runs against the veteran Dodgers pitcher—and his solid home run production against left-handed pitchers this season, makes him a favored choice to hit a homer on Friday. According to SportsLine’s model, Machado is poised for a home run at +360 odds, reflecting strong confidence in his performance.
Alongside Machado, other promising home run picks include Zachary Neto of the Angels and Wilyer Abreu from the Red Sox. Both players have favorable matchups and impressive recent form, enriching the range of MLB home run picks available for bettors on Friday. SportsLine’s proven computer model simulates every game 10,000 times, providing credible data on potential outcomes and value bets.

Insights on Wilyer Abreu’s Power Potential
Wilyer Abreu has demonstrated consistent hitting, with three multi-hit games in his last four outings, though he has not homered recently. Returning to home turf, where Abreu’s home run rate is higher, presents an advantage. Notably, 20 of his 21 home runs this season have come against right-handed pitchers, and he is set to face Sandy Alcantara, who has struggled recently, giving up 11 earned runs over his last two starts.
Alcantara has posted a .939 OPS during 10 road starts this season, indicating vulnerability that Abreu might capitalize on. SportsLine values Abreu’s chances with a projected line around +410, but bettors can find odds as high as +500 at FanDuel, adding to the appeal of wagering on this hitter.
Zachary Neto’s Rising Confidence After Sweeping the Dodgers
Zachary Neto and the Los Angeles Angels have gained momentum by sweeping the Dodgers, which should boost his confidence heading into Friday’s game. A right-handed hitter, Neto has hit better against right-handed pitching, registering a .286 average and 14 of his 19 home runs this season against RHPs.
Neto faces rookie pitcher Jack Perkins of the Oakland Athletics, who has shown vulnerability in Sacramento’s hitter-friendly ballpark. The SportsLine model sets Neto’s home run line around +380, while FanDuel offers this pick at +420, presenting a favorable betting opportunity supported by recent team performance and individual statistics.
Manny Machado’s Advantageous Matchup Against Clayton Kershaw
Machado’s record against Clayton Kershaw is exceptional. Hitting 13-for-42 with four home runs against the future Hall of Famer, Machado’s history suggests he could break his current 13-game home run drought on Friday. This “he’s due” narrative aligns with his season stats showing 10 home runs in 131 at-bats against lefties and 10 homers in 335 at-bats versus righties.
The matchup against left-handed Kershaw enhances Machado’s odds, and his stronger road performance—an .892 OPS away from home versus .805 OPS at home—supports betting on him in San Diego. SportsLine’s model placed Machado’s home run line at +250, but bettors can currently secure this at +360 on FanDuel, offering significant value in light of his form and history.
Where to Place MLB Home Run Bets on August 15
Several sportsbooks will offer home run prop bets on Friday’s MLB games. Among the prominent platforms are FanDuel, DraftKings, Caesars, BetMGM, Fanatics, and bet365, each providing varied promotions and bonus incentives.
FanDuel stands out by offering $300 in bonus bets if your first wager of $5 or more wins, along with odds like +360 for Machado, +420 for Neto, and +500 for Abreu. DraftKings also provides a $200 bonus plus discounts on NFL Sunday Ticket, while BetMGM offers bonus bets up to $1,500 if your initial bet loses. These promotions enhance potential returns for bettors while supporting multiple MLB prop betting options.
Additional Home Run Picks to Watch
Besides the highlighted players, the SportsLine Projection Model continues to analyze and update MLB home run picks daily, incorporating data from all games and players. This dynamic system has maintained a strong winning record, up 56.9 units on its MLB home run selections this season, and delivered significant payouts on multi-leg parlays.
Sports bettors seeking detailed player-by-player projections and recommendations can consult SportsLine’s daily blog for the latest insights and betting strategies heading into Friday’s games.
Implications for MLB Betting on August 15
Friday’s matchups in the National League West and beyond offer promising opportunities for home run bettors, especially with Manny Machado prominently positioned to extend his power surge. His success against Kershaw and recent hitting streak contribute to a compelling case for backing him as a home run pick. Meanwhile, Wilyer Abreu and Zachary Neto bring additional value with strong matchups and recent form.
With sportsbooks presenting various promotions aimed at maximizing bettors’ stakes and the support of a robust projection model, August 15 is shaping up to be an exciting night for MLB home run prop wagers. The unfolding contests and emerging star performances will likely influence wagering trends as the season progresses.